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Nexus Kedokteran Translasional
Published by Universitas Sebelas Maret
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
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Articles 6 Documents
 1 
Search results for , issue "Vol 1, No 2 (2012): Nexus Kedokteran Translasional" : 6 Documents clear
Efek Hepatoprotektor Ekstrak Daun Dandang Gendis (Clinacanthus nutans) terhadap Kadar SGPT Tikus Putih (Rattus novergicus) yang Diinduksi Parasetamol Sasongko, Devi Purnamasari; Subandono, Jarot; ., Martini
Nexus Kedokteran Translasional Vol 1, No 2 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.205 KB)

Abstract

Background: Paracetamol was a safe drug, but would cause oxidative stress if  taken too much.. Dandang gendis leaves contained a flavonoid antioxidant. This research intended to prove the antioxidant effect of dandang gendis leaves that could prevent liver cell damage of white rat induced by paracetamol. Methods: This research was an experimental laboratoric with post test only control group design. This research had taken place at Parasitology and Micology Faculty of Medicine Sebelas Maret University Surakarta. The sample was 32  Wistar white rats. The dependent variable was the SGPT level of white rats and the independent variable was the dandang gendis leaves extract. The white rats were divided into 4 groups: negative control group (KK0), positive control group (KK1), first threated group (KP1), and second threated group (KP2). KP1 had been given 30 mg/200 gr BB dose and KP2 had been given 60 mg/200 gr BB dose for 14 days. At 11th –  13th days, the white rats from KK1, KP1, and KP2 had been given 291.6 mg/200 gr BB dose of paracetamol. At 14th day, rat’s blood had been taken from orbitalis sinus. The damage of the liver cell had been measured with SGPT laboratory test. The data had been analyzed with one way ANOVA test then with post hoc test (α = 0.05). Results: The highest rate of SGPT levels was KK1, following KP1, KP2, and the lowest was KK0. Oneway ANOVA test resuls showed a significant difference among the four groups with p = 0.000. Post hoc test results showed a significant difference between KK0 – KK1 (p = 0.003) and KK0 – KP2 (p = 0.019) whereas between KK0 – KP1 (p = 0.204), KK1 – KP1 (p = 0.885), KK1 – KP2 (p = 0.077), and KP1 – KP2 (p = 0.932) had no significant difference. Conclusion: Giving dandang gendis leaves extract was not  significant to raise the SGPT level of white rat induced by paracetamol. Raising dandang gendis leaves extract doses was not significant to raise its hepatoprotector effect. Keywords: dandang gendis leaf, SGPT, white rat, hepatoprotector, paracetamol
Efek Hepatoprotektor Ekstrak Tempe Kedelai pada Mencit (Mus musculus) yang Diinduksi Parasetamol Arifyanto, Elanda Rahmat; Widjokongko, S. Bambang; Sjarifah, Ipop
Nexus Kedokteran Translasional Vol 1, No 2 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.205 KB)

Abstract

Background: Soybean tempeh is known to contain various kinds of antioxidants such as vitamin C, vitamin E, vitamin B2, saponins, isoflavones, phytic acid, lecithin, iron, and phytosterol. Antioxidants are thought to be hepatoprotective. The objective of this research is to know the influence of soybean tempeh extract to the liver histological damage of mice (Mus musculus) and the increase of soybean tempeh extract dose can also increase protection effect to the liver histological damage of mice (Mus musculus) which is induced by paracetamol.   Methods: This was laboratory experimental research with the post test only controlled group design. Samples were 32 male mice, Swiss webster type, 2-3 months old age and ± 20 g of each weight. Samples were divided into 4 groups of 8 mice each. Sampling technique used in this research was incidental sampling. Mice for control group (K) and P1 group will be given aquadest for 14 days in a row. The P2 and P3 group will be given soybean tempeh extracts dose for 14 days in a row. Soybean tempeh extracts dose in each group was 2.2 mg/20 g weight of mice and 4.4 mg/20 g weight of mice. Paracetamol will be given to P1, P2, and P3, with dose 5 mg/20g weight of mice on the 12th to 14th days. On the 15th day, hepar of mice was taken and stainned with Hematoxylin Eosin (HE) for histopathological study. The hepar cells of mice were observed microscopically by counting the number of necrosis cells on the centrolobuler zone. The data were analyzed by Oneway ANOVA test and Post Hoc test (α=0.05).   Results:The average damage of hepar cells in the K, P1, P2, P3 were 20.75 ± 1.58; 85.00 ± 2.98; 43.75 ± 2.92; 31.00±2.00consecutively. The results of Oneway ANOVA test showed a significant difference in all group (p < 0.05). The results of Post Hoc test showed significant differences between K – P1, K – P2, K – P3, P1 – P2, P1 – P3, and P2 – P3 with p < 0.05.   Conclusion: The soybean tempeh extracts can prevent the histological damage of the hepar cells of mice (Mus musculus) and the increase of soybean tempeh extracts dose followed by the increase of protection effect to the liver cell damaging of mice which is induced by paracetamol.   Key words: soybean tempeh extract, paracetamol, liver histological damaging.
Efek Diuresis Ekstrak Propolis pada Tikus Putih Jantan (Rattus Norvegicus) Fadityo, .; Doewes, Muchsin; ., Kisrini
Nexus Kedokteran Translasional Vol 1, No 2 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.205 KB)

Abstract

Background:Diuretics are medicine that increase the amount of  urine volume. Propolis has 150 compounds that have biological activities, one of the is flavonoid. Flavonoid known to has diuretic effect. Methods:The research is a laboratory experimental analytic study using randomized controlled trial done at Laboratory of Setia Budi University Surakarta in June 2012. The research subject is a number of 35 male white rats of Wistar strain. They were divided into five treatment groups, each group consists of seven rats. Simple random sampling is used for sampling technique. Before the treatment,  rats were adapted for 7 days and fasted for 48 hours but still provided with drinking water. Propolis extract was given orally. Group I was given aquadest 2.5 ml as negative control, group II was given hydrochlorothiazide 0.3 mg/2.5 ml as positive control, group III was given propolis extract at dose 30 mg/2.5 ml as dose I, group IV was given propolis extract at dose 60 mg/2.5 ml as dose II, and group V was given propolis extract at dose 120 mg/2.5 ml as dose III. Rats urine volume was measured every 6 hours for 24 hours. Results:Result of statistic calculation using Anova test with p < 0.05 shows that there is significant difference in total rats urine volume between group I, II, III, IV, and V. The Post-Hoc test result between group I compared with the others group was significant difference.Group II has the largest urine volume from all groups. Group III has the largest urine volume among the groups that given propolis extract. Group IV has larger urine volume than group V and group V has the least urin volume among the groups that given propolis extract. Conclusions:Through observing amount of urine volume and statistic calculation, it can be concluded that propolis extract has diuretic effect in the male white rats.The increase of propolis extract dose cause the decrease of urine volume. Keywords:Propolis extract, hidroclorotiazid, diuretic
Efek Hepatoprotektor Ekstrak Daun Dandang Gendis (Clinacanthus nutans) terhadap Kadar SGPT Tikus Putih (Rattus novergicus) yang Diinduksi Parasetamol Devi Purnamasari Sasongko; Jarot Subandono; Martini .
Nexus Kedokteran Translasional Vol 1, No 2 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.205 KB)

Abstract

Background: Paracetamol was a safe drug, but would cause oxidative stress if taken too much.. Dandang gendis leaves contained a flavonoid antioxidant. This research intended to prove the antioxidant effect of dandang gendis leaves that could prevent liver cell damage of white rat induced by paracetamol. Methods: This research was an experimental laboratoric with post test only control group design. This research had taken place at Parasitology and Micology Faculty of Medicine Sebelas Maret University Surakarta. The sample was 32 Wistar white rats. The dependent variable was the SGPT level of white rats and the independent variable was the dandang gendis leaves extract. The white rats were divided into 4 groups: negative control group (KK0), positive control group (KK1), first threated group (KP1), and second threated group (KP2). KP1 had been given 30 mg/200 gr BB dose and KP2 had been given 60 mg/200 gr BB dose for 14 days. At 11th 13th days, the white rats from KK1, KP1, and KP2 had been given 291.6 mg/200 gr BB dose of paracetamol. At 14th day, rats blood had been taken from orbitalis sinus. The damage of the liver cell had been measured with SGPT laboratory test. The data had been analyzed with one way ANOVA test then with post hoc test (? = 0.05). Results: The highest rate of SGPT levels was KK1, following KP1, KP2, and the lowest was KK0. Oneway ANOVA test resuls showed a significant difference among the four groups with p = 0.000. Post hoc test results showed a significant difference between KK0 KK1 (p = 0.003) and KK0 KP2 (p = 0.019) whereas between KK0 KP1 (p = 0.204), KK1 KP1 (p = 0.885), KK1 KP2 (p = 0.077), and KP1 KP2 (p = 0.932) had no significant difference. Conclusion: Giving dandang gendis leaves extract was not significant to raise the SGPT level of white rat induced by paracetamol. Raising dandang gendis leaves extract doses was not significant to raise its hepatoprotector effect. Keywords: dandang gendis leaf, SGPT, white rat, hepatoprotector, paracetamol
Efek Hepatoprotektor Ekstrak Tempe Kedelai pada Mencit (Mus musculus) yang Diinduksi Parasetamol Elanda Rahmat Arifyanto; S. Bambang Widjokongko; Ipop Sjarifah
Nexus Kedokteran Translasional Vol 1, No 2 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.205 KB)

Abstract

Background: Soybean tempeh is known to contain various kinds of antioxidants such as vitamin C, vitamin E, vitamin B2, saponins, isoflavones, phytic acid, lecithin, iron, and phytosterol. Antioxidants are thought to be hepatoprotective. The objective of this research is to know the influence of soybean tempeh extract to the liver histological damage of mice (Mus musculus) and the increase of soybean tempeh extract dose can also increase protection effect to the liver histological damage of mice (Mus musculus) which is induced by paracetamol. Methods: This was laboratory experimental research with the post test only controlled group design. Samples were 32 male mice, Swiss webster type, 2-3 months old age and 20 g of each weight. Samples were divided into 4 groups of 8 mice each. Sampling technique used in this research was incidental sampling. Mice for control group (K) and P1 group will be given aquadest for 14 days in a row. The P2 and P3 group will be given soybean tempeh extracts dose for 14 days in a row. Soybean tempeh extracts dose in each group was 2.2 mg/20 g weight of mice and 4.4 mg/20 g weight of mice. Paracetamol will be given to P1, P2, and P3, with dose 5 mg/20g weight of mice on the 12th to 14th days. On the 15th day, hepar of mice was taken and stainned with Hematoxylin Eosin (HE) for histopathological study. The hepar cells of mice were observedmicroscopically by counting the number of necrosis cells on the centrolobuler zone. The data were analyzedby Oneway ANOVA test and Post Hoc test (?=0.05). Results:The average damage of hepar cells in the K, P1, P2, P3 were 20.75 1.58; 85.00 2.98; 43.75 2.92; 31.002.00consecutively. The results of Oneway ANOVA test showed a significant difference in all group (p < 0.05). The results of Post Hoc test showed significant differences between K P1, K P2, K P3, P1 P2, P1 P3, and P2 P3 with p < 0.05. Conclusion: The soybean tempeh extracts can prevent the histological damage of the hepar cells of mice (Mus musculus) and the increase of soybean tempeh extracts dose followed by the increase of protection effect to the liver cell damaging of mice which is induced by paracetamol. Key words: soybean tempeh extract, paracetamol, liver histological damaging.
Efek Diuresis Ekstrak Propolis pada Tikus Putih Jantan (Rattus Norvegicus) . Fadityo; Muchsin Doewes; Kisrini .
Nexus Kedokteran Translasional Vol 1, No 2 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.205 KB)

Abstract

Background:Diuretics are medicine that increase the amount of urine volume. Propolis has 150 compounds that have biological activities, one of the is flavonoid. Flavonoid known to has diuretic effect. Methods:The research is a laboratory experimental analytic study using randomized controlled trial done at Laboratory of Setia Budi University Surakarta in June 2012. The research subject is a number of 35 male white rats of Wistar strain. They were divided into five treatment groups, each group consists of seven rats. Simple random sampling is used for sampling technique. Before the treatment, rats were adapted for 7 days and fasted for 48 hours but still provided with drinking water. Propolis extract was given orally. Group I was given aquadest 2.5 ml as negative control, group II was given hydrochlorothiazide 0.3 mg/2.5 ml as positive control, group III was given propolis extract at dose 30 mg/2.5 ml as dose I, group IV was given propolis extract at dose 60 mg/2.5 ml as dose II, and group V was given propolis extract at dose 120 mg/2.5 ml as dose III. Rats urine volume was measured every 6 hours for 24 hours. Results:Result of statistic calculation using Anova test with p < 0.05 shows that there is significant difference in total rats urine volume between group I, II, III, IV, and V. The Post-Hoc test result between group I compared with the others group was significant difference.Group II has the largest urine volume from all groups. Group III has the largest urine volume among the groups that given propolis extract. Group IV has larger urine volume than group V and group V has the least urin volume among the groups that given propolis extract. Conclusions:Through observing amount of urine volume and statistic calculation, it can be concluded that propolis extract has diuretic effect in the male white rats.The increase of propolis extract dose cause the decrease of urine volume. Keywords:Propolis extract, hidroclorotiazid, diuretic

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